Pharmaceutical Sciences

FORMULATION STUDIES OF ACACIA SIEBERIANA GUM IN CHOROQUINE AND METRONIDAZOLE MATRIX TABLETS

ABSTRACTThe crude plant gum from African Acacia sieberiana was purified and investigated for use as a matrix excipient for chloroquine phosphate and metronidazole tablet formulations. The chromatographic analysis of the acid hydrolysed gum revealed the presence of rhamnose, galactose, ribose, xyl...

Pharmaceutical Sciences Type: PROJECT

📄 98 pages | 🧠 9245 words | 📚 5 chapters

786 views

EVALUATION OF THE DISSOLUTION AND OTHER CHARACTERISTICS OF CYCLODEXTRIN MOLECULAR INCLUSION COMPLEXES OF ARTEMETHER

ABSTRACTThe present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-β-cyclodextrin. The solid complexes of artemether and hydroxypropyl-β-cyclodextrin...

Pharmaceutical Sciences Type: PROJECT

📄 92 pages | 🧠 8799 words | 📚 5 chapters

795 views

EVALUATING GENOMIC DEOXYRIBONUCLEIC ACID (gDNA) OF PARENTS AND OFFSPRING TOWARDS DETERMINING RICKETS HEREDITARY LINK IN GONIN GORA

A CASE STUDY OF KASO AND JANKASA COMMUNITIES IN KADUNA STATE

ABSTRACTRickets is still a debilitating disease in various communities of Jankasa, Kaso and Gonin Gora in which about 3-7 percent of the population is affected. Genomic Deoxyribonucleic acid (gDNA) of parents and offspring were evaluated towards determining rickets hereditary link in the populati...

Pharmaceutical Sciences Type: PROJECT

📄 97 pages | 🧠 9242 words | 📚 5 chapters

726 views

COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS

ABSTRACTThe influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the...

Pharmaceutical Sciences Type: PROJECT

📄 96 pages | 🧠 9225 words | 📚 5 chapters

657 views

ANTIBIOTICS SUSCEPTIBILITY AND MOLECULAR CHARACTERIZATION OF CLINICAL ISOLATES OF E. coli

A CASE STUDY OF AHMADU BELLO UNIVERSITY TEACHING HOSPITAL SHIKA, ZARIA

ABSTRACTAntimicrobial drug resistance is a global challenge with the emergence of resistant bacterial strains worldwide. This study was conducted to determine the incidence of E. coli in ABUTH Shika, Zaria (from March 2011 to February 2012), their antibiotics susceptibility pattern, molecular cha...

Pharmaceutical Sciences Type: PROJECT

📄 90 pages | 🧠 9498 words | 📚 5 chapters

613 views

MOLECULAR CHARACTERIZATION OF MULTIDRUG RESISTANT BACTERIAL UROPATHOGENS FROM PREGNANT WOMEN

A CASE STUDY OF IBADAN METROPOLIS, SOUTH-WEST NIGERIA

ABSTRACTUrinary tract infection (UTI) is one of the commonest infectious diseases of women worldwide, and pregnant women are more predisposed. This study aimed to determine the prevalence of bacterial infecting agents in UTI during pregnancy, to establish their antimicrobial susceptibility profil...

Pharmaceutical Sciences Type: PROJECT

📄 88 pages | 🧠 6394 words | 📚 5 chapters

654 views

ANTIDIARRHOEAL AND TOXICITY STUDIES ON METHANOL LEAF EXTRACT OF COMBRETUM HYPOPILINUM DIELS (COMBRETACEAE) IN MICE AND RATS

ABSTRACTThe plant Combretum hypopilinum has been used in traditional medicine to treat diarrhoea and other gastrointestinal diseases. This study aimed to investigate the antidiarrhoeal activity and toxicity profile of the methanol leaf extract of Combretum hypopilinum (MECH) in mice and rats. The...

Pharmaceutical Sciences Type: PROJECT

📄 100 pages | 🧠 11075 words | 📚 5 chapters

639 views

DEVELOPMENT OF A FILLER-BINDER DISINTEGRANT FOR DIRECT COMPRESSION TABLETING BY CO-PROCESSING MICROCRYSTALLINE CELLULOSE AND CROSPOVIDONE

ABSTRACTThe aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to optimize the...

Pharmaceutical Sciences Type: PROJECT

📄 93 pages | 🧠 7804 words | 📚 5 chapters

709 views

ASSESSING THE ORAL HEALTH RECORDS AND ANTIBIOGRAM OF ANAEROBIC BACTERIA ISOLATES FROM PATIENTS VISITING DENTAL UNIT

A CASE STUDY OF AHMADU BELLO UNIVERSITY MEDICAL CENTER, ZARIA

ABSTRACTOral health can be a good indicator of general health and has been linked to systemic diseases, therefore, maintaining good oral hygiene is important. Oral infections are polymicrobial with dental caries and periodontal disease being the major oral conditions affecting the public. A retro...

Pharmaceutical Sciences Type: PROJECT

📄 91 pages | 🧠 11370 words | 📚 5 chapters

590 views

COMPARATIVE IN-VITRO BIOEQUIVALENCE STUDIES OF SOME BRANDS OF METRONIDAZOLE TABLET MARKETED IN ZARIA, KADUNA STATE

ABSTRACTMetronidazole is an antibacterial and antiprotozoal drug used in the treatment of amebiasis, giardiasis, trichomoniasis and other microbial diseases. It is an essential drug commonly found in Nigerian market and has so many generics and dosage forms under various trade names by different ...

Pharmaceutical Sciences Type: PROJECT

📄 80 pages | 🧠 11998 words | 📚 5 chapters

625 views

CONTROLLED RELEASE FORMULATIONS OF ANTIRETROVIRAL (ARV) DRUGS USING POLYMETHACRYLATE POLYMERS

ABSTRACTTo improve patient compliance and ensure better success in the management of HIV, spansule technology was employed to formulate controlled release dosage drug. Generic forms of seven of the most commonly used Anti-retro viral (ARV) drugs (didanosine, indinavir, lamivudine, nelfinavir, nev...

Pharmaceutical Sciences Type: PROJECT

📄 93 pages | 🧠 7798 words | 📚 5 chapters

609 views

COMPARISON OF THE EFFECT OF A SINGLE ORAL DOSE OF CIMETIDINE AND PROPANTHELINE ON THE PHARMACOKINETIC OF PARACETAMOL IN HUMAN

ABSTRACTComparison of the effects of a single oral dose of cimetidine and propantheline on the pharmacokinetics of paracetamol were studied with paracetamol (1g) administered alone, concurrently with cimetidine (400mg), delay (1 hour) with cimetidine (400mg), concurrently with paracetamol (15mg) ...

Pharmaceutical Sciences Type: PROJECT

📄 83 pages | 🧠 10273 words | 📚 5 chapters

546 views

INCIDENCE OF MULTIDRUG RESISTANT STAPHYLOCOCCUS AUREUS AND ENTEROBACTERIACEAE FROM GROUNDNUT CAKES (KULI-KULI) AND ROASTED GROUNDNUTS OBTAINED FROM ZARIA METROPOLIS

ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans. Previous studies reported the identification of MRSA in food demonstrating that food can represent a source of Staphylococcus aureus which may carry the mecA ...

Pharmaceutical Sciences Type: PROJECT

📄 90 pages | 🧠 9851 words | 📚 5 chapters

541 views

PHARMACOGNOSTIC AND BIOLOGICAL STUDIES OF THE LEAVES AND STEM-BARK OF HYMENOCARDIA ACIDA, TUL. (EUPHORBIACEAE)

ABSTRACTThis study deals with the pharmacognostic and biological aspects of the leaves and stem bark of Hymenocardia acida Tul (Family Euphorbiaceae). Euphorbiceae is a large and heterogeneous family found mainly in the tropics and sub-tropics. H. acida is a savannah shrub or tree with twisted tr...

Pharmaceutical Sciences Type: PROJECT

📄 88 pages | 🧠 12753 words | 📚 5 chapters

605 views

PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON THE LEAF EXTRACT OF STEREOSPERMUM KUNTHIANUM (BIGNONIACEAE)

ABSTRACTStereospermum kunthianum (Bignoniacea) herb is used in Hausa ethnomedicine in treating bronchitis, veneral diseases, diarrheoa and dysentery. It is also used in the treatment of ulcers, leprosy, skin eruptions, respiratory ailments and gastritis. The plant is common in Northern Nigeria wh...

Pharmaceutical Sciences Type: PROJECT

📄 89 pages | 🧠 9204 words | 📚 5 chapters

600 views