Pharmaceutical Sciences

DESIGN, SYNTHESIS, ANTIMALARIAL EVALUATION AND COMPUTATIONAL STUDIES OF SOME CHALCONE DERIVATIVES

ABSTRACTInspired by the previous findings on the structural requirements needed for good antimalarial activity by chalcones against Plasmodium proteases, seventeen chalcone derivatives were designed and synthesized using Claisen-Schmidt condensation of appropriate aldehydes and methyl ketones. Th...

Pharmaceutical Sciences Type: PROJECT

📄 99 pages | 🧠 11635 words | 📚 5 chapters

307 views

EFFECT OF LAURIC ACID ON ERECTILE AND TESTICULAR DYSFUNCTION IN DIABETIC MALE WISTAR RATS

ABSTRACTDiabetes mellitus is a risk factor for reproductive and sexual dysfunction. Standard medications are not completely satisfactory, hence the consideration of natural products as an alternative therapy. Lauric acid is the most abundant constituent of coconut oil, which is renowned for its t...

Pharmaceutical Sciences Type: PROJECT

📄 85 pages | 🧠 11499 words | 📚 5 chapters

294 views

PHYTOCHEMICAL AND ANTI SNAKE VENOM STUDIES ON THE METHANOL AERIAL PART EXTRACT OF TACAZZEA APICULATA OLIV (PERIPLOCACEAE)

ABSTRACTTacazzea apiculata (Olive) is a woody climber indigenous to Tropical Africa often used in traditional medicine for the treatment of pain, inflammation, skin infections, diabetes, epilepsy and snakebite. This study aimed to isolate and characterize some of the phytochemical constituent(s) ...

Pharmaceutical Sciences Type: PROJECT

📄 96 pages | 🧠 9360 words | 📚 5 chapters

319 views

PHYTOCHEMICAL, ANALGESIC AND ANTI-INFLAMMATORY STUDIES ON THE METHANOL ROOT EXTRACT OF COMBRETUM HYPOPILINUM (DIELS) OKAFOR (COMBRETACEAE)

ABSTRACTCombretum hypopilinum (Diels) Okafor belongs to the family Combretaceae, and composed of 20 genera with about 500 species. It is a small to medium sized, deciduous shrub or tree growing from 4 - 18 metres in height, with a rounded or flat heavy crown. The plant is used in ethnomedicine fo...

Pharmaceutical Sciences Type: PROJECT

📄 86 pages | 🧠 6765 words | 📚 5 chapters

457 views

EFFECT OF CO-ADMINISTRATION OF METFORMIN AND CEFIXIME ON SOME BIOMARKERS IN DIABETIC RATS

ABSTRACTThe incidence of infections in Type 2 Diabetes Mellitus (T2DM) continues to be on the increase, necessitating the combined use of antibiotics and hypoglycaemic agents. Metformin, a biguanide is the first drug of choice in the management of T2DM and is most frequently employed with antibio...

Pharmaceutical Sciences Type: PROJECT

📄 98 pages | 🧠 7287 words | 📚 5 chapters

283 views