ABSTRACT
In this report, the Wmgerodt-Kindler reaction has
been reviewed, and a. variant of the reaction has "been
developed.
In this, good yields of thioamides have been obtained
"by reaction of aldehydes or ketones with salts of volatil e
amines and anhydrous sodium acetate in dimethylformamide
at moderate temperatures, thus avoiding the conventional
use of pressure vessels and high temperatures.
The thioamides with alkyl halides give S-alkylquaternary salts, which have been reacted with various
nucleophilic reagents: hydrazine hydrate, sodium borohydride and diazomethane: giving interesting products.
