This study examined the profitability and efficiency of catfish production in Kuje Area Council of the Federal Capital Territory, Abuja, Nigeria. Purposive random sampling technique was used to sample 60 catfish farmers from whom the primary data used were collected with the aid of structured questionnaire. The data were analysed using descriptive statistics, net farm income and stochastic frontier production function. The study revealed that the mean age, household size and fish farming experience of the respondents were 42 years, 11 and 6 years respectively. Most (86.7%) of the respondents were male (86.7%). Catfish farming was found to be profitable with net farm income of â‚Â�1,772,195.00. The mean technical, allocative and economic efficiencies were 73%, 59% and 43% respectively. The study also showed that economic efficiency of catfish farmers in the study area can be improved substantially(57%) with more improvement in cost allocation. Major constraints encountered by catfish farmers were high cost of feed, water inadequacy, capital insufficiency and rodent attack. The study recommended that local feed research that would help reduce cost of feed should be encouraged