A comparative study was conducted to evaluate the effect of cotton products (WCS and CSC) on performance, carcass characteristics and organs function of Red Sokoto bucks. A total of 24 bucks weighing averagely 8.625kg were randomly assigned to six diets formulated to contain 14% Crude Protein in a complete diet. The diets contained 10, 20 and 30% inclusion levels of Whole Cotton Seed (WCS) and Cotton Seed Cake (CSC) each and bucks were fed 4% of their body weights throughout the trial period of 90 days in a 2 x 3 factorial arrangement in a completely randomized design. Growth performance, digestibility and nitrogen balance, haematology and carcass characteristics, as well as organ functions were all studied. Results obtained showed that all the evaluations differed significantly at either the main effect of cotton products, inclusion levels and the interaction. Total weight gain (TWG) differed significantly (p<0.05) in bucks fed WCS (1.125kg) and CSC (1.833kg) with CSC performing better. Also, 20% (2.00kg) inclusion of cotton products (WCS and CSC) performed better than 10% (1.125kg) and 30% (1.313kg). Similar results were obtained for the interaction effect of cotton products and inclusion levels. Bucks fed WCS and CSC did not differ significantly (p>0.05) in digestibility study although, a significant difference (p<0.05) was obtained for inclusion levels of WCS and CSC with 20% (67.346%) inclusion level performing better than 30% (59.989) and 10% (49.843%) being the least for dry matter (DM), organic matter (66.484, 58.511 and 48.044), crude protein (78.077,76.046 and 63.725%), Neutral detergent fibre (68.587, 65.264 and 57.511%) and Acid detergent fibre (76.860, 72.046 and 63.725%) respectively. Nitrogen retained as percent intake was higher in bucks fed CSC (53.026%) comparedto WCS (48.435%)treated group while 30% inclusion level of cotton products retained more nitrogen (62.47 compared to 53.24 and 36.480%) of 20 and 10% respectively which differed (p<0.05) significantly. There vii was a significant difference (p<0.05) of cotton products on total protein (6.563 and 7.431 g/day), Packed Cell Volume, PCV (26.8 and 34.333%), heamoglobin, Hg (8.840 and 11.417 g/dl), Red Blood Cell, RBC (4.473 and 5.833 *10^6/l) and neutrophil (59.6 and 77.167%) for WCS and CSC respectively with CSC having the highest values all through the measured parameters. There was significant (p<0.05) difference in the inclusion levels of cotton products in the Blood Urea Nitrogen BUN, (69.330, 42.530 and 58.440μmol/dl) for 10, 20 and 30% respectively with 10% inclusion being the highest value followed by 30 and 20%. Neutrophil followed the same order while albumin (12.733, 23.333 and 23.333 μmol/l), PCV (29.889, 26.444 and 34.111%), Hg (10.033, 8.789 and 11.133g/l) and RBC (4.978, 4.589 and 5.867*10^6/l) differed significantly (p<0.05) on bucks fed 10, 20 and 30% inclusion levels with 30% being the highest value obtained. The interaction of cotton products and inclusion levels for most parameters measured differed significantly (p<0.05) except for BUN and monocytes counts. Using WCS or CSC had no significant effect (p>0.05) on hot carcass weight, dressing percentage and organ weights although, inclusion level of these products affected hot carcass weight, dressing percentage, empty small intestine and lungs weights significantly with 30% inclusion having the highest value and 20% the lowest value for the parameters observed. Similarly, prime cuts of leg, chump and main rib differed significantly for the effect of cotton products with WCS having better muscle development compared to CSC treated group. It can be concluded that, the use of either WCS and CSC, and their inclusion at various levels will give a similar result although, for better digestibility and nutrient absorption, CSC is more preferable at 20% inclusion