Study on the genetics of witchweed (Striga hermonthica (Del.) Benth) resistance in sorghum (Sorghum bicolor (L) Moench) was conducted in a randomised complete block design experiment at the Institute for Agricultural Research Samaru, (Northern Guinea Savanna 110 11' N: 70 38' E, 686m) Zaria, Kaduna state, Nigeria. Five sorghum varieties: two Striga resistant varieties (ICSR94405 and ICSR94407) and three susceptible varieties, (SAMSORG40, SAMSORG14 and SAMSORG17) were used for the study. The study was undertaken to determine the variability for resistance to Striga and other agronomic traits in sorghum, to determine inheritance of resistance to Striga in sorghum, gene action involved in the inheritance of Striga resistance in sorghum, and to determine genetic advance for Striga resistance and other agronomic traits in sorghum. The resistant varieties used as male parents were crossed to the susceptible parents which were the females and F1, F2 and backcross populations were generated. The six populations: P1, P2, F1. F2, BC1P1, and BC1P2 were evaluated at IAR Samaru Striga sick plot in 2012. The result revealed highly significant difference among the genotypes for the traits studied. The result showed that additive gene action is more important for the inheritance of Striga resistance in sorghum. Inheritance of resistance to Striga in the F2 populations involving the male parent: ICSR94407 is controlled by two dominant genes which are complementary, while in F2 populations involving ICSR94405; it is controlled in part by genes at two or more loci. Also high heritability and genetic advance were observed for almost all the traits studied, indicating; positive response, repeatable and transmitability of these traits in selection.