The proliferation of drugs as a global cancer, has eaten deep into the healthof the general public. It is the greatest evil of our time and the highest weapon of terrorism against public health, as well as an act of economic sabotagethat has led to organ dysfunction, disabilities, worsening of disease condition, loss of public confidence in public health and led to the death of many in the globe and Nigeria is not an exception.Most of these drugs are brought into the state and not necessarily produced within Kaduna State threatening the health of the people in the state. It is for this reason that the Federal Government of Nigeria established NAFDACwith the goal of eliminating counterfeit pharmaceuticals, foods and beverages products ensuring that available medications are safe and effective. This necessitated the need to assess the activities of NAFDAC in the control of fake drugs in Kaduna State.The specific objectives of the study are to determine the effect of the contribution of inspection of imported regulated products by NAFDAC on the control of fake drugs in Kaduna State; to examine the contribution of registration of drugs by NAFDAC on the control of fake drugs in Kaduna Stateamongst others. The study adopted "Fishbein Model and Social Control Theory by Travis Hirschi‟‟ as theoretical framework to underpin the study. The study adopted a survey design where data collected from structured questionnaires and interview were analyzed using both descriptive and inferential statistics. The total population of the study is 1, 664 with 313 as sample size. The study adopted purposive and simple stratified sampling technique for the study. The chi-square cross-tabulation test was used in testing hypotheses of the study using SSPS version 20.However, relevant documents that contain secondary data for the study are the NAFDAC‟s Act, NAFDAC‟s Score Cards, and NAFDAC‟s Campaigns, amongst others. The findings of the study shows that some of the factors affecting the inspection of drugs in Kaduna State ranges from shortage of personnel or inspectors to monitor drug activities in Kaduna State due to large coverage size, shortage of scan machines to enable personnel detect fake drugs easily to even chaotic drug market in the state. Hence, the study recommends that the government should be willing to recruit new hands who are specialist in their various fields of endeavor having the technical-know-how to help NAFDAC in the execution of her activities and to ensure adequate coverage of the state in other to carry out routine checks, etc. Furthermore, the government should continue to empower NAFDAC to strengthen her efforts in the control of fake drugs in the state by acquiring modern machines to upgrade the central laboratory and promote manpower training and development. These, will go a long way to discouraging counterfeiters or fakers of drugs and reducing the quantum of existing fake drugs in the state