This study determined the relationship between job stress and job efficiency of agricultural education academic staff in colleges of education North-west, Nigeria. The study made use of survey research design with a total population of one hundred and sixty six (166) academic staff who served as the sample size for the study. Two research questions and two null hypotheses were formulated. The instrument used for data collection was relationship between job stress and job efficiency of academic staff questionnaire. Data collected were analyzed using descriptive statistics inform frequency count, percentages and mean to answer the research question. Pearson Product Moment Correlation Coefficient (PPMC) statistic was used to test the two null hypotheses at 0.05 or 5% level of significance. The findings indicated that the calculated p value of 0.004 and 0.001 were lower than 0.05 alpha values at correlation index r level of -0.654 and -0.801 respectively, hence the null hypotheses were rejected. Findings of the study further showed that, teaching large class of up to 500 students provoked stress on the lectures which affects academic job efficiency. It was also found that lecturing work combining with the administrative work such as head of department, coordination of programs like field trip and teaching practice result to academic job stress. It was concluded that excess workload combined with administrative responsibilities lowers job efficiency of academic staff. It was recommended that more academic staff should be employed to reduce the workload that rendered academic staff inefficient.