The study has examined the influence of teacher interactive variable on students' performance. This study has also examined the relationship between Teachers' Interactive Variables such as interest, qualification, attitude, experience and self-efficacy on students' academic achievement in Islamic Studies of Senior Secondary School in Kaduna state. This was found to be paramount because Islamic studies education needs more attention than any subject owing to its enormous contributions to the moral development of youth and old people in the societies and country in general. The interest, attitude and qualification of Islamic Studies teachers play a vital role in any learning process. The implementation of any curriculum depends on societal needs and availability of teaching personnel and their willingness to impact the desired knowledge to learners. The study was set to investigate the impact of teacher interactive variables on students' performance in Islamic studies in Senior Secondary schools of Kaduna state. The respondents of the study comprise of 338 secondary school principals, teachers, supervisors and school administrators. Questionnaire was used as the instrument for data collection. The data collected were analyzed using Simple frequencies mean and standard deviation was used for the research questions and f-test (ANOVA), and (PPMR) correlation coefficient was used to test the hypotheses. Analysis of Variance (ANOVA) and Correlation coefficient was used to retain or reject the null hypotheses. The study used survey research design and applied the method of James sampling in which every two thousand six hundred and fifty (2650) and above, one should take three hundred and thirty as sample size of the research. The result revealed that teacher interactive variables had significant correlation with students' academic performance in Islamic Studies. Although one hypothesis was retain which accept that experience as no any impact on students' academic achievement. The study recommended that it is high time for Islamic studies teachers to further their education and to have positive changes in their attitude towards the teaching of the subject so that the achievement of Islamic studies goals will not be hindered. Furthermore, the stakeholders of Secondary School education are called upon to ensure that only teachers who are qualified and have interest to teach the subject are employed. Attention of curriculum reviewers has also been drawn to the fact that they should design the Islamic Studies curriculum so that it will dance to the tune of the present of society.