This study assessed The Influence of Entrepreneurship Education Component of Nigerian Certificate in Education (NCE) Home Economics Programme on Graduates in North East Nigeria. The study was necessitated by the prevailing unemployment situation and increase in crime and its social vices among Colleges of Education NCE graduates in North East geo-political zone, Nigeria. The study had five (5) objectives, five (5) research questions and five (5) null hypotheses. Descriptive survey design was used to carry out the research. From a population of one thousand, two hundred (1200), a sample of two hundred and ninety-one (291) was drawn using purposive sampling technique. An adopted questionnaire was employed to obtain data for the study. Two hundred and ninety one (291) questionnaire were distributed but only two hundred and eighty nine (289) were successful completed and used for the study. The data were analyzed using descriptive and inferential statistics. Mean and standard deviation were used to answer the six research questions. Pearson Product Moment Correlation (PPMC) was used to test null hypotheses one (1) to five (5), at 0.05 alpha level of significance. The findings revealed among others that the NCE Home Economics programme has significant influence on the application of entrepreneurial skills among graduates of Home Economics in North-East Geo-political zone, Nigeria. It was concluded that Home Economics application influences entrepreneurship skills among Colleges of Education graduates in North-East Geo-political Zone, Nigeria. It was recommended among others that teachers of Home Economic should teach all the component in full. The teachers should take into consideration the expected teaching strategies of meeting up with the NCCE minimum standard. The present situation in Nigeria requires entrepreneurial skill application that would enable Home Economics graduates to acquire skills and competencies for self-reliant. There should be effective teaching and exposure to practical learning of entrepreneurial skills to enhance its application.