The purpose of this study was to assess relationship between work- related stress and job satisfaction among secondary school teachers in North-West Zone, Nigeria. To achieve this purpose, the variables assessed in this study include physical environment, psychological, socio-economic, and health in relation to work- related stress and job satisfaction among public secondary school teachers. Ex-post facto research design was used for the study. A self-developed questionnaire with six statements on each of the variables investigated was vetted by the supervisors from the Department of Physical and Health Education. A pilot study was conducted to test the reliability of the instrument. The data collected were coded and analysed for reliability and internal consistency using Statistical Package for the Social Sciences (IBM Version 23).Cronbach?s Alpha was .915, Spearman Brown Equal and Unequal Length was .781, and Guttman Split- Half test of .715 were used to further determine the validity and the reliability of the instrument. The instrument was then administered on six hundred and sixty five (665) teachers from twenty-eight (28) sampled public secondary schools from 14 Senatorial districts in North-West Zone, Nigeria through random sampling procedure while 613 were retrieved and used. The data collected were statistically analyzed thus: for the demographic variables, frequencies and percentage, mean and standard deviation, were used to analyze work related stress and job satisfaction among secondary school teachers in North West Zone, Nigeria. Pearson product moment correlation coefficient was used to test the formulated hypotheses 3,4,5,6. One simple t-test was used for sub-hypotheses 1& 2 to establish the significance of the expressed opinion on the investigated variables of stress and job satisfaction. All hypotheses were tested at 0.05 level of significance. The findings reveal that the teachers are highly stressed and this has affected their job satisfaction, On the findings, physical environment, psychological, Socio-economic and Health work-related stress are significantly correlated with teachers? job satisfaction in North West Zone. It was concluded that State ministries of education and the school management should improve on provision of facilities and equipment for conducive teaching and learning environment. It was further recommended that the Federal and State Ministries of Education should ensure immediate review and improvement of condition of services in terms of wages, incentives and develop a policy on stress management to guide the induction, operations and counselling of teachers at all levels in their day to day duties, to enhance teaching.