This study was aimed at examining the Parents?, Teachers? and students? perception of drug abuse and its influence on academic performance among adolescents in Secondary Schools in Niger state, Nigeria. Four research questions guided the study and four corresponding null hypotheses were tested at 0.05 level of confidence. The study sample included 162 parents, 60 teachers and 162 adolescents, making a total of 384 sampled respondents for the study. The descriptive survey design was used. Relevant literature reviewed were cited. The instrument for data collection was a questionnaire that was validated and tested for reliability. Both descriptive and inferential statistics were used for data analysis. Frequency counts, percentages and means were used while the hypotheses were tested using Analysis of Variance (ANOVA). The responses on the drug abuse and its influence on academic performance among adolescent students in Secondary Schools in Niger state were both positive and significant. Their major perceptions were that, drug abuse by adolescents lower their academic performance; both parents and the students were of the view that male students who keep bad friends were likely to fall into drug abuse; teachers were of the opinion that male students who have no basic future of livelihood may resort to drug abuse. It was concluded that all the respondents irrespective of their status have almost the same level of perception on what influences adolescents? drug abuse and that drug abuse can result to into negative consequences including lower academic performance. It was recommended among others that parents and teachers should monitor the type of peer groups their adolescents keep, as peer group influence, is the major cause of adolescent drug abuse. It was also recommended that drug education should be integrated into Home -Economics curriculum at all levels of education.