The crude plant gum from African Acacia sieberiana was purified and investigated for use as a matrix excipient for chloroquine phosphate and metronidazole tablet formulations. The chromatographic analysis of the acid hydrolysed gum revealed the presence of rhamnose, galactose, ribose, xylose and fructose. The viscosity was found to increase with in... Continue Reading
The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-?-cyclodextrin. The solid complexes of artemether and hydroxypropyl-?-cyclodextrin (HP-?-CD) were prepared at a molar ratio of 1:1, 1:2 and 1:3... Continue Reading
Rickets is still a debilitating disease in various communities of Jankasa, Kaso and Gonin Gora in which about 3-7 percent of the population is affected. Genomic Deoxyribonucleic acid (gDNA) of parents and offspring were evaluated towards determining rickets hereditary link in the population. Four families from Jankasa, Kaso and two families from Go... Continue Reading
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the five sessions with a 2 weeks wash out period in-between. Par... Continue Reading
Antimicrobial drug resistance is a global challenge with the emergence of resistant bacterial strains worldwide. This study was conducted to determine the incidence of E. coli in ABUTH Shika, Zaria (from March 2011 to February 2012), their antibiotics susceptibility pattern, molecular characterization and possible presence of E. coli serotype O157:... Continue Reading
Urinary tract infection (UTI) is one of the commonest infectious diseases of women worldwide, and pregnant women are more predisposed. This study aimed to determine the prevalence of bacterial infecting agents in UTI during pregnancy, to establish their antimicrobial susceptibility profiles, identify the socio-economic factors that promote UTI. Vir... Continue Reading
The plant Combretum hypopilinum has been used in traditional medicine to treat diarrhoea and other gastrointestinal diseases. This study aimed to investigate the antidiarrhoeal activity and toxicity profile of the methanol leaf extract of Combretum hypopilinum (MECH) in mice and rats. The phytochemical screening was conducted and the oral median le... Continue Reading
The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to optimize the composition of the co-processed excipient (CPE). The optimiz... Continue Reading
Oral health can be a good indicator of general health and has been linked to systemic diseases, therefore, maintaining good oral hygiene is important. Oral infections are polymicrobial with dental caries and periodontal disease being the major oral conditions affecting the public. A retrospective study on patients with orodontal conditions in the d... Continue Reading
Metronidazole is an antibacterial and antiprotozoal drug used in the treatment of amebiasis, giardiasis, trichomoniasis and other microbial diseases. It is an essential drug commonly found in Nigerian market and has so many generics and dosage forms under various trade names by different manufacturers. The purpose of the study was to evaluate and c... Continue Reading
To improve patient compliance and ensure better success in the management of HIV, spansule technology was employed to formulate controlled release dosage drug. Generic forms of seven of the most commonly used Anti-retro viral (ARV) drugs (didanosine, indinavir, lamivudine, nelfinavir, nevirapine, stavudine and zidovudine) and their clinically appro... Continue Reading
Comparison of the effects of a single oral dose of cimetidine and propantheline on the pharmacokinetics of paracetamol were studied with paracetamol (1g) administered alone, concurrently with cimetidine (400mg), delay (1 hour) with cimetidine (400mg), concurrently with paracetamol (15mg) and delay (1 hour) with propantheline (15mg) respectively. Pa... Continue Reading
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans. Previous studies reported the identification of MRSA in food demonstrating that food can represent a source of Staphylococcus aureus which may carry the mecA gene. The aim of this study is to determine the incidence of ... Continue Reading
This study deals with the pharmacognostic and biological aspects of the leaves and stem bark of Hymenocardia acida Tul (Family Euphorbiaceae). Euphorbiceae is a large and heterogeneous family found mainly in the tropics and sub-tropics. H. acida is a savannah shrub or tree with twisted trunk usually less than 4.5 m high but sometimes attaining as m... Continue Reading
Stereospermum kunthianum (Bignoniacea) herb is used in Hausa ethnomedicine in treating bronchitis, veneral diseases, diarrheoa and dysentery. It is also used in the treatment of ulcers, leprosy, skin eruptions, respiratory ailments and gastritis. The plant is common in Northern Nigeria where it is used as abortifacient and as antihypertensive agent... Continue Reading