THE EFFECT OF WATER EXTRACT OF COLA NITIDA POD ON LIPOPROTEIN CONCENTRATIONS OF ALBINO WISTAR RATS

Cola nitida has been in use in the eastern parts of Nigeria for the
management of certain ailments and as an aphrodisiac in the
management of some sexual dysfunctions. However the effects of this
extract in some health parameters in human objects have not been
reported. This work, then, was aimed at investigating the effect of
water extracts of kola pods on lipoprotein concentrations on albino
wistar rats.
Rats were used in this study and they were divided into several groups
and fed with a high calorie food (cowâ€s brain) so as to increase the
blood lipoprotein concentration in the rat models. The effect of the
water extracts of the sample used was compared with a known drug
and the results statistically compared to ascertain the effect of the
water extract on the rat models.
The results of this work indicate that water extracts of cola nitida pods
can be used in the management of mild lipoprotein dysfunctions thus
substantiating the reasons for its use in sexual erectile functions.

Title page

Approval page - - - - - - - - i

Dedication -- - - - - - - - ii

Acknowledgment - - - - - - - iii

Abstract - - - - - - - - - iv

Table of contents - - - - - - - - v

1.0 Introduction - - - - - - - - 1

2.0 Literature Review - - - - - - 2

2.1 Kola Nut Powered (Cola Nitida) - - - - 2

2.2 Kola pod components - - - - - - 3

2.3 Geography and distribution - - - - - 4

2.4 Lipoprotein - - - - - - - 5

2.5 High cholesterol diagnosis - - - - - 9

2.6 Low cholesterol - - - - - - - 9

2.7 Changes during circulation - - - - - 12

2.8 Liver - - - - - - - - 13

3.1 Identification and Extraction plant material - - 16

3.2 Phytochemical Analysis - - - - - 17

3.3 Experimental Animal model - - - - - 22

3.4 Collection of Blood samples - - - - - 24

3.5 Lipid profile Analysis - - - - - - 24

Results

Phytochemical composition of samples - - - - 31

Discussion and conclusion

5.1 Discussion -- - - - - - - 34

5.2 Conclusion -- - - - - - - 35